B chromosomes (Bs) are supernumerary chromosomes which are often preferentially inherited, deviating from usual Mendelian segregation. The balance between the so-called chromosome drive and the negative effects that the presence of Bs applies on the fitness of their host determines the frequency of Bs in a particular population. Advances in genome analysis and chromosome imaging improved our knowledge on the origin and drive of Bs. In contrast to the prevalent view that Bs do not harbour genes recent analysis revealed that Bs of sequenced species are rich in gene-derived sequences. I will summarize the latest findings on supernumerary chromosomes of rye (Secale cerelae) and the goatgrass Aegilops speltoides with a special focus on the origin and drive of B chromosomes. Novel CRISPR-Cas9 based chromatin imaging methods will be introduced to elucidate the spatio-temporal organization of the genome inside the nucleus. How novel analytical tools will expand our ability to uncover the biology of B chromosomes will be discussed.
B chromosomes (Bs) are supernumerary chromosomes which are often preferentially inherited, deviating from usual Mendelian segregation. The balance between the so-called chromosome drive and the negative effects that the presence of Bs applies on the fitness of their host determines the frequency of Bs in a particular population. Advances in genome analysis and chromosome imaging improved our knowledge on the origin and drive of Bs. In contrast to the prevalent view that Bs do not harbour genes recent analysis revealed that Bs of sequenced species are rich in gene-derived sequences. I will summarize the latest findings on supernumerary chromosomes of rye (Secale cerelae) and the goatgrass Aegilops speltoides with a special focus on the origin and drive of B chromosomes. Novel CRISPR-Cas9 based chromatin imaging methods will be introduced to elucidate the spatio-temporal organization of the genome inside the nucleus. How novel analytical tools will expand our ability to uncover the biology of B chromosomes will be discussed.
2B9 - Building 2 GSA2018_APCC6 GSACC62018@canberra.edu.auTechnical Issues?
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